A cookbook for DNase Hi-C
نویسندگان
چکیده
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UNLABELLED Genome-wide proximity ligation assays, e.g. Hi-C and its variant TCC, have recently become important tools to study spatial genome organization. Removing biases from chromatin contact matrices generated by such techniques is a critical preprocessing step of subsequent analyses. The continuing decline of sequencing costs has led to an ever-improving resolution of the Hi-C data, result...
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The folding and three-dimensional (3D) organization of chromatin in the nucleus critically impacts genome function. The past decade has witnessed rapid advances in genomic tools for delineating 3D genome architecture. Among them, chromosome conformation capture (3C)-based methods such as Hi-C are the most widely used techniques for mapping chromatin interactions. However, traditional Hi-C proto...
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ژورنال
عنوان ژورنال: Epigenetics & Chromatin
سال: 2021
ISSN: 1756-8935
DOI: 10.1186/s13072-021-00389-5